Sevilla have been unable to end their early struggles, losing at promoted Alaves 4-3 for a second straight defeat to start the Spanish league season.
Sevilla also fell to Manchester City on penalties in the UEFA Super Cup final last week.
But a double from Kike Garcia five minutes apart midway through the second half secured promoted Alaves the victory.
Back in the top flight after a year in the second tier, Alaves also scored twice in the first half, through Luis Rioja and Ruben Duarte, in a match that went to the break at two apiece.
Having fallen behind early, Sevilla moved 2-1 ahead thanks to an own-goal by Abdel Abqar and a strike from Erik Lamela, before Duarte levelled for the hosts.
Rafa Mir added the visitors' third deep into second-half stoppage time but it was too little, too late.
Sevilla have now failed to win in their last six league games going back to last season, with two draws and four losses.
Rayo Vallecano won at promoted Granada 2-0 to join Real Madrid and Valencia in starting the La Liga campaign with two straight victories.
Alvaro Garcia and Pathe Ciss scored second-half goals for the visitors, in a match that was twice interrupted by power outages.
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